Metrics details. Many factors may lead to sperm DNA damage. However, it is little known that the correlations of sperm DNA damage with obesity-associated markers, and reproductive hormones and lipids levels in serum and seminal plasma.
We read with interest the commentary by Dr. Pandiyan and colleagues 1 about the merit of our recently published clinical practice guidelines for sperm DNA fragmentation SDF testing based on clinical scenarios 2. We noted that these authors were quite skeptic about the integration of SDF testing into the clinical workup of male infertility and management algorithms for couples embarking on assisted reproductive technology ART.
Mike Berkley. Chromatin is that portion of the cell nucleus which contains the entire DNA of the nucleus in animal or plant cells. DNA damage may be present in sperm from both fertile and infertile men.
A spermatozoon joins an ovum to form a zygote. A zygote is a single cell, with a complete set of chromosomesthat normally develops into an embryo. Sperm cells contribute approximately half of the nuclear genetic information to the diploid offspring excluding, in most cases, mitochondrial DNA.
News Ticker. Sperm may contain hidden DNA damage. The sperm of infertile men may look and behave normally, but have hidden genetic damage that could stop them producing a child.
As a part of standard infertility work up, sperm parameters should be tested with a semen analysis. Sperm analysis should be done after days of abstinence and not more than 10 days. If any of the parameter s is abnormal, it should be repeated for confirmation of that abnormal parameter s and in the absence of sperm azoospermia or with poor semen parameters urological evaluation is recommended.
Chromatin is that portion of the cell nucleus which contains the entire DNA of the nucleus in animal or plant cells. DNA damage may be present in sperm from both fertile and infertile men. Therefore, this sperm DNA damage analysis may reveal a hidden abnormality of sperm DNA in infertile men classified as unexplained based on apparently normal standard sperm parameters.
The standard sperm analysis which measures sperm count, motility and morphology has been around for more than one hundred years. Today we rely on the computer to define these parameters for us much more accurately and reliably. What has NOT changed is that that while an overtly abnormal sperm analysis regardless of how it is performed allows for the diagnosis of male infertilityintermediate values are often difficult to interpret.