Lobular carcinoma breast cancer

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Invasive lobular carcinoma is a type of breast cancer that begins in the milk-producing glands lobules of the breast. Invasive cancer means the cancer cells have broken out of the lobule where they began and have the potential to spread to the lymph nodes and other areas of the body. Invasive lobular carcinoma makes up a small portion of all breast cancers.

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Lobular breast cancer, also called invasive lobular carcinoma ILCoccurs in the breast lobes or lobules. Lobules are the areas of the breast that produce milk. ILC is the second most common type of breast cancer.

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Metrics details. Tumours are generally of a good prognostic phenotype, being low histological grade and low mitotic index, hormone receptor positive and HER2, p53 and basal marker negative, and with a generally good response to endocrine therapy. Despite this, clinicians face countless challenges in the diagnosis and long-term management of patients, as they encounter a tumour that can be difficult to detect through screening, elicits a very invasive nature, a propensity for widespread metastatic colonisation and, consequently, in some studies a worse long-term poor outcome compared with invasive carcinoma of no special type.

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Lobular carcinoma starts in the groups of glands that make milk called lobules. It may be non-invasive called lobular carcinoma in situ or invasive. LCIS is a buildup of abnormal cells in the lobules. These cells do not spread outside the lobules into nearby breast tissue.

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Invasive Lobular Carcinoma ILCalso known as infiltrating lobular carcinoma, is the second most common form of breast cancer diagnosed in the United States, representing percent of diagnosed invasive breast cancers. This type of cancer is more difficult to see on imaging because of the way the cells stream through the breast tissue. Invasive lobular carcinomas are usually larger than expected from the mammogram.

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Metrics details. Invasive lobular and ductal carcinomas differ with respect to risk factors. Invasive lobular carcinoma is more strongly associated with exposure to female hormones, and therefore its incidence is more subject to variation.

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An important part of diagnosing breast cancer is staging. Staging is the process of finding out how much cancer there is and where it is located. This information is used to plan cancer treatment and develop a prognosis.

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Because it is less common than infiltrating ductal carcinoma IDCfew data have been reported that address the biologic features of ILC in the context of their clinical outcome. In the present study we undertook an extensive comparison of ILC and IDC using a large database to provide a more complete and reliable assessment of their biologic phenotypes and clinical behaviors. The clinical and biological features of patients with ILC were compared with those of 45, patients with IDC not otherwise specified.

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Lobular breast cancer also called invasive lobular carcinoma is a type of breast cancer that begins in the milk-producing glands lobules of the breast. Invasive means that the cancer has invaded or spread from its original contained location — in this case, from within the walls of the lobule -- into the surrounding breast tissue. Over time, invasive lobular breast cancer can also spread to the lymph nodes in the underarms, beneath the breast or inside the chest or to other areas in the body away from the breast.

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Invasive lobular carcinoma is the second most common type of breast cancer. It affects the lobules of the breast, which are the structures that contain the glands that produce breast milk. According to the American Cancer Societyabout 10 percent of people who get invasive breast cancer have invasive lobular carcinoma ILC. Approximately 80 percent of people with invasive breast cancer have invasive ductal carcinoma IDC.

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